Investigation of potential targets and their inhibitors in mycobacterium tuberculosis

Verma, Ankit

dc.contributor.author	Verma, Ankit
dc.date.accessioned	2024-10-03T10:18:12Z
dc.date.available	2024-10-03T10:18:12Z
dc.date.issued	2024-09-01
dc.identifier.uri	http://hdl.handle.net/123456789/459
dc.description	Supervisor: Dr. Sanjay Gupta Co-supervisor: Dr. Vijay Kumar	en_US
dc.description.abstract	Mycobacterium tuberculosis (MTB) poses a significant global health threat due to its rapid development of drug resistance, making it difficult to monitor, treat, and prevent tuberculosis (TB) effectively. As a result, scientists have heightened their efforts in exploring novel bioactive substances that possess a unique mechanism of action when combating drug-resistant strains of Mycobacterium tuberculosis. In this study, a high-throughput virtual screening of 30,417 compounds from three independent repositories against putative antitubercular targets, namely MmpL, GlfT2, and MurB, involved in cell-wall biosynthesis was performed. Seventy-five top-ranked inhibitors for further evaluation have been identified.	en_US
dc.language.iso	en	en_US
dc.publisher	SRHU	en_US
dc.subject	Drug resistance	en_US
dc.subject	Mycobacterium tuberculosis	en_US
dc.subject	Cell wall	en_US
dc.subject	Potential targets	en_US
dc.subject	Inhibitors	en_US
dc.subject	Drug discovery	en_US
dc.title	Investigation of potential targets and their inhibitors in mycobacterium tuberculosis	en_US
dc.type	Thesis	en_US