INVESTIGATION OF POTENTIAL TARGETS AND THEIR INHIBITORS IN MYCOBACTERIUM TUBERCULOSIS

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dc.contributor.authorVerma, Ankit
dc.date.accessioned2025-04-12T05:36:47Z
dc.date.issued2024-09-01
dc.descriptionSupervisor: Dr. Sanjay Gupta Co-supervisor: Dr. Vijay Kumar
dc.description.abstractMycobacterium tuberculosis (MTB) poses a significant global health threat due to its rapid development of drug resistance, making it difficult to monitor, treat, and prevent tuberculosis (TB) effectively. As a result, scientists have heightened their efforts in exploring novel bioactive substances that possess a unique mechanism of action when combating drug-resistant strains of Mycobacterium tuberculosis. In this study, a high-throughput virtual screening of 30,417 compounds from three independent repositories against putative antitubercular targets, namely MmpL, GlfT2, and MurB, involved in cell-wall biosynthesis was performed. Seventy-five top-ranked inhibitors for further evaluation have been identified.
dc.identifier.urihttp://10.0.2.76:4000/handle/123456789/27
dc.language.isoen
dc.publisherSRHU
dc.titleINVESTIGATION OF POTENTIAL TARGETS AND THEIR INHIBITORS IN MYCOBACTERIUM TUBERCULOSIS
dc.typeThesis

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