Thesis & Dissertation

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Start date: 2020End date: 2024

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    Dermatoglyphics in type II diabetes mellitus
    (SRHU, 2022-10-25) Srivatsva, Shubha
    Dermatoglyphics in type H DM has been studied with views to jdentjfy significance of dermatoglyphics for early detection of patients with type H DM and identjfyjng normal people who are prone to Type 11 DM.
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    Effect of formalin on respiratory system of albino rats: A histological study
    (SRHU, 2022-10-25) Gupta, Monika
    Formaldehyde (formalin) is a widely used industrial chemical and is also present in vehicle emissions & embalming fluid. Widespread occurrence of formaldehyde alarmed scientists to see its possible effects on living systems. In a number of previous studies, it was found genotoxic and carcinogenic to animals including rats, monkeys and hamsters etc. Multiple studies were also done on humans to see its possible carcinogenic effects. This study was conducted to see the histological effects of formalin on the respiratory tract of albino rats. 60 rats were taken for the experiment which were divided into 3 groups. 6 rats were used as controls while 3 subgroups of 18 rats each were exposed to formalin inhalation for 9, 18 and 36 days respectively.
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    An Anatomico-clinical Correlation between nasal shptal Deviation and chronic sinus disease
    (SRHU, 2022-10-26) Arora, Mani
    In the present study, we evaluated the role of septal deviation in pathogenesis of chronic sinusitis. As said, nasal septum deviation may cause obstruction at the ostiomeatal unit. This obstruction may trap fluid in a sinus and causing chronic sinusitis.
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    Morphological and Histo-pathological Study of placenta in anaemic mothers
    (SRHU, 2022-10-26) Munjal, Shashi
    tritional anaemia is the most wide spread nutritional disorder in the world affecting 30% of the worlds population and is more common among the expecting mothers. Severity of anaemia among expectant mother was judged by the criteria suggested by wHol. In the present study moaphological and histopathological changes in placenta of anaemic mother is undertaken to study effects of aneamia on gestational age of mothers, foetal outcome, moaphology of placenta (weight, volume, diameter, cotyledon and fibrin deposition) and histopathological changes in the placenta
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    Estimation of Foetal cephalic index in Utero during various periods of Pregnancy by Ultrasonogram and their correlation to gestational age In the Garhwali population
    (SRHU, 2022-10-16) Puri, Rashmi
    Estimation of the exact date of confinement by the obstetricians has been for a long time calculated by the Nagele's rule (LMP plus 7 days minus 3 months). Estimation of an accurate gestational age is essential by which an obstetrician will be successful in managing an antenatal patient. Many a times the patients do not remember their exact date of LMP. Estimation of gestationalage on the basis of measurement of the biparietal diameter by the ultrasonographic methods is being followed in most of the hospital.Various workers like Hadlock et al6, Berger et al2°, Dewhurst et a|2', Sabbagha eta| 23 Campbell 24, Parker et a| 26, Dubowitz and Goldberg et al 27, Okupe et a| 28, Varma 32 have observed the changes in the BPD at various gestational ages. They have also laid down the various table by which gestational age can be estimated by a given BPD.
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    Dermatoglyphics in coronary artery Disease
    (SRHU, 2022-10-26) Panchal, Padamjeet
    Dermatoglyphics is a scientific method of analyzing of ridge patterns by studying finger and palmar prints, which are under genetic control. Dermatoglyphics analysis has been established as a useful diagnostic and research tool in genetics, medicine, and anthropology. The etiology of coronary heart disease is believed to be multifactorial with genetics playing an important role. Vndations in dermatoglyphics in such patients are therefore, expected.
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    Histomorphological Study of coronary artery
    (SRHU, 2022-10-26) Sinha, Priti
    Coronary artery disease is one of the major cause of death in developing countries. Failure to understand normal coronary anatomy and distinguish between normal and anomalous structures may lead to misinterpretations and disastrous complications during coronary interventions and heart surgery.
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    Effect of Vigabatrin on central Nervous system of albino rats
    (SRHU, 2022-10-26) Singh, Deepa
    Vigabatrin is an antiepileptic drug that has demonstrated significant efficacy as adjunctive therapy for patients with poorly controlled partial epilepsy, refractory to other antiepileptic drugs. It is the drug of choice for infantile spasms. In the present study, Vigabatrin was administered to albino rats in mild, moderate and high doses. Vacuolation was a significant finding in all treated groups and in all regions of the central nervous system that were studied, with severity increasing with increasing doses. IME secondary to elevated levels of GABA may underlie the pathogenesis. Demyelination was found at a few selected sites suggesting that different parts of the brain have different affinity for this feature after treatment with Vigabatrin. In the cerebellum and retina, significant degenerative and atrophic changes were seen even in mild dose treated group.. Focal neuronal and neuroglial loss was mainly evident in these two parts suggesting that they are the main targets of toxic damage by Vigabatrin. Congested blood vessels and dilated perivascular spaces, found in all regions under study, were signs of edema. The involvement of retina explains the high incidence of visual field defects associated with the use of this drug. Present study has also demonstrated histopathological involvement 90 of the cerebellum which suggests that further extended studies should be done and should be correlated with the cerebellar functions.
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    Histomorphological study of Lymphoid organs in fetuses
    (SRHU, 2022-10-26) Dubey, Aksh
    In the present study, development of the lymphoid organs thymus, spleen, lymph node, palatine tonsil and peyer's patches were studied histomolphologically in developing fetuses. Thymus developed initially in the region of neck and then migrated to anterior mediastianum. Lymphocytes first appeared in the thymus at the 9th week, trabeculae developed from the 9th week onwards, lobulation started to develop at the 9th week and continued till the 12th week, corticomedullary differentiation was apparent during the period of 9th to 14th week, Hassell's corpuscles first appeared at the 15th week.
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    Effects of fluoxetine (SSRI) on the urogenital system of albino rats
    (SRHU, 2022-10-26) Aggarwal, Alka
    Sexual disorders are the common side effects of SSRI group of antidepressants, although, recently SSRIs have emerged as an effective new treatment modality for premature ejaculation in a dose of 40 mg/day. Some evidences suggest that SSRIs can cause untoward sexual experiences such as changes in sexual desire, sexual performance and sexual satisfaction. Reliable estimates of the incidence and severity of untoward experiences are difficult to obtain, however, in part because patients and physicians may be reluctant to discuss them. Accordingly, estimates of the incidence of untoward sexual experience and performance, cited in product labeling, are likely to underestimate their actual incidence. In patients eurolled in U.S. major depressive disorder, OCD and bulimia nervosa placebo-controlled clinical trials, decreased libido was the only sexual side effect. There are no adequate and well controlled studies examining sexual dysfunction with Fluoxetine treatment. There have been spontaneous reports in women taking Fluoxetine of orgasmic dysfunction, including anorgasmia. Because Fluoxetine is prototype of SSRIs and most commonly used in different doses for different psychiatric disorders such as for depression and phobias in low doses i.e.10 and 20 mg/day but in high doses up to 80 mg/day for OCD and bulimia nervosa. For almost all the psychiatric illnesses the SSRIs are used for long duration. Therefore, the 86 objective of the present study was to deduce the comparative safety of Fluoxetine in acute and subacute therapy and to study the histological changes in various cells of urogenital system of albino rats after intraperitoneal injection of Fluoxetine in different doses. 72 albino rats viere taken for the study which was conducted in 3 phases of 2, 4 and 12 weeks duration. Each phase consisted of 24 rats. These 24 rats were further subdivided into 4 groups of 6 rats each (3 males and 3 females). Group 1 (Control) received intraperitoneal injection of vehicle (normal saline). Group 2, Group 3 and Group 4 received 10 mg, 20 mg and 40 mg/kg of body weight/day intraperitoneal injection of Fluoxetine respectively.