Browsing by Author "Verma, Ankit"

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    INVESTIGATION OF POTENTIAL TARGETS AND THEIR INHIBITORS IN MYCOBACTERIUM TUBERCULOSIS
    (SRHU, 2024-09-01) Verma, Ankit
    Mycobacterium tuberculosis (MTB) poses a significant global health threat due to its rapid development of drug resistance, making it difficult to monitor, treat, and prevent tuberculosis (TB) effectively. As a result, scientists have heightened their efforts in exploring novel bioactive substances that possess a unique mechanism of action when combating drug-resistant strains of Mycobacterium tuberculosis. In this study, a high-throughput virtual screening of 30,417 compounds from three independent repositories against putative antitubercular targets, namely MmpL, GlfT2, and MurB, involved in cell-wall biosynthesis was performed. Seventy-five top-ranked inhibitors for further evaluation have been identified.